ABSTRACT
Breast cancer is the one of the most frequent neoplasm in women. In the last decades, detection of disease in earlier clinical stages has improved prognosis, however five-year disease-free survival still remains at about 72%. For this reason, continuing efforts to establish reliable prognostic markers are made. The presence of lymph node metastasis is one of the most important prognostic factors in breast cancer. Studies show that D2-40 immuno-stain demonstrated a significant higher detection of LVI as compared with routine H&E staining in early breast cancer. LVI is associated with axillary lymph node metastases and a long-term prognostic factor. A precise identification of LVI would have a strong clinical impact for breast cancer patients. In this study, we aim to demonstrated.LVI as a significant predictor of poor prognosis in patients with lymph node-negative patients with primary invasive breast cancer and its association with other known parameters such as tumour size, tumour grade, nodal metastasis and age
ABSTRACT
Thrombocytopenia is defined as platelet count < 1.5 lakhs/cumm. It is the commonest platelet abnormality observed in clinical practice with differentclinical expression. Thrombocytopenias in hematological malignancies are clonal proliferations of the malignant hematopoietic stem cells characterized by the accumulation of blasts principally in the marrow at the cost of impaired production of normal blood cells.The aim of the present study was to evaluate thrombocytopenia in cases of hematological malignancies with study of clinical profile and laboratory parameters in patients with thrombocytopenia.The present study had maximum numbers of patients were in the age group 20-39 years (8cases). Patients with platelet count more than 150 x 109/L, patients presented with massive hemorrhage, and who received massive colloid or crystalloid transfusion for volume loss are not included in our study. The maximum number of patients presenting with thrombocytopenia were males (18 cases).It was concluded that chronic lymphocytic leukemia are more common than other hematological malignancy cases